Abstract: Conjunctivochalasisis (CCh) not uncommon but often was overlooked as a normal aging variation. The etiology of conjunctivochalasis has not yet to be fully elucidated. Recent studies showed that overexpression of matrix metalloproteinases by conjunctivochalasis fibroblasts, which may help explain how conjunctivochalasis manifests excessive degradation of the conjunctival matrix and Tenon’s capsule, which could cause the lack of adhesion between the conjunctiva and the sclera and conjunctivochalasis. The redundant conjunctiva located between the globe and the eyelid interferes tear meniscus, causing unstable tear film, punctal occlusion and delayed tear clearance. The accumulation of inflammatory protein, apoptosis and apoptosis related proteins and degrading enzymes or other active ingredient in tear fluid are increased due to the delay in tear clearing. Inflammatory cytokines up\|regulate the expression of matrix metalloproteinases by conjunctival fibroblasts, which will promote the further degradation of conjunctival extracellular matrix, setting up a vicious cycle to aggravate the existing conjunctivochalasisis.  (Int Rev Ophthalmol, 2015, 39： 130-134)